Lipid-binding allergens from Dermatophagoides pteronyssinus mites extract isolated by liposomes
نویسندگان
چکیده
Background House dust mites (HDM), including Dermatophagoides pteronyssinus (Dpt) and Dermatophagoides farinae (Df), are one of the commonest aeroallergens worldwide eliciting allergic manifestations [1]. Allergenic phenomenon is tightly associated both with the mites themselves and with ligands derived from mite-associated bacterial/fungal products. Some Dpt allergens belong of lipid-binding proteins, including Der p 2 (protein with myeloid differentiation protein 2 (MD-2) related lipid recognition domain), Der p 7 (structurally homologous to lipid binding protein family) and Der p 13 (lipid transporter molecule) [2]. Thus, in this study we aimed to evaluate the ability of liposomes to adsorb lipid-binding proteins from Dermatophagoites pteronyssinus mites extract.
منابع مشابه
The house dust mite Dermatophagoides pteronyssinus is the most important allergen on the island of Mauritius.
To determine the relative importance of mites as a cause of allergic sensitivity and asthma on the western Indian Ocean island of Mauritius, we measured specific IgE antibodies to common inhalant allergens in sera from Mauritians claiming to have allergic symptoms and we examined house dust samples for evidence of mites and their allergens. Seventy-two of the 110 sera tested (65%) contained det...
متن کاملStandardization of House Dust Mite Extracts in Korea
PURPOSE House dust mites are the most important cause of respiratory allergy in Korea. Standardization of allergen extracts is essential for improving diagnostics and immunotherapeutics. This study was undertaken to evaluate the allergenicity of standardized house dust mite allergen extracts from Korean house dust mite isolates. METHODS Allergen extracts were prepared from cultured Korean hou...
متن کاملAnaphylaxis caused by flaxseed
Methods and results Prick-prick carried out with flaxseed showed a strong positivity. Skin prick test to inhaled allergens were positive to mites, dog and cat danders, plain tree and grasses. Skin prick test to food allergens were positive to almond, hazelnut, peanut, chestnut, walnut, mustard, lentils, soybeans, rice, oat, corn and lupine. Total IgE was: 291 UI/ml. Specific IgE (CAP, ThermoFis...
متن کاملSelective allergy to lobster in a case of primary sensitization to house dust mites.
Allergy to only 1 kind of seafood is uncommon. We report a case of selective allergy to lobster. We studied a 30-year-old man who suffered generalized urticaria, facial erythema, and pharyngeal pruritus after eating lobster. He had a more than 10-year history of mild persistent asthma and sensitization to house dust mites. The study was performed by skin prick test, and prick-prick test, oral f...
متن کاملProteases of Dermatophagoides pteronyssinus
Since the discovery that Der p 1 is a cysteine protease, the role of proteolytic activity in allergic sensitization has been explored. There are many allergens with proteolytic activity; however, exposure from dust mites is not limited to allergens. In this paper, genomic, transcriptomic and proteomic data on Dermatophagoides pteronyssinus (DP) was mined for information regarding the complete d...
متن کامل